Objectifs
Cette formation a pour objectif de mieux maîtriser et comprendre les relations existantes entre pharmacocinétique et pharmacodynamie (DMPK).
Ce module de formation abordera ce sujet de manière théorique et pratique (calculs PK avec le programme WinNonlin).
Contenu
BASIC CONCEPTS
Absorption
- mechanisms and steps involved in the absorption process
- oral absorption: physiological considerations (pH, GIT motility, etc)
- oral absorption: physicochemical characteristics of drug substance
- non-oral routes of administration
- presystemic elimination
- transporters and efflux pumps
Distribution
- perfusion/diffusion limitation in drug distribution
- binding to plasma and tissue macromolecules
- apparent volume of distribution
Elimination
- clearance concept
- renal excretion mechanisms
- biliary excretion
- metabolism: phase I and phase II reactions, sites of metabolism, interindividual bariability
- transporters
MULTIPLE DOSE PHARMACOKINETCS
- accumulation to steady state: iv infusion, multiple iv bolus injections, and multiple oral dose administration
- linear vs. non-linear pharmacokinetics
PHARMACOKINETIC ANALYSIS: THEORY
- noncompartmental analysis: AUC and AUMC, CL, Vd, t½, …
- compartmental analysis: 1- and 2-compartmental models
- population pharmacokinetics
PHARMACOKINETIC ANALYSIS: EXAMPLES
- several Cp-time data sets will be analyzed by using the WinNonlin software package by the noncompartmental and compartmental approaches |