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Gallium-68 Automated Generator and Equipments
Key words : Gallium-68, Germanium-68, Generator, PET, Radiotracer
Consortium
- Companies : Trasis (coordinator), IRE-Elit
- Research centers : Ulg (Centre de Recherches du Cyclotron), CHU Liège (Service de Médecine Nucléaire), FUNDP (Laboratoire d'analyses par réactions nucléaires)
Topic of the project
In positron emission tomography (PET), 18F-fluorine was and is still widely used because of both its favorable chemical and radiophysical properties. Nevertheless, it necessitates the proximity of a cyclotron due to its 110 minutes half life. Gallium-68, with its 68 minutes half life, has the dual advantage to be independent of daily delivery, because it is issued from a generator. Moreover, it allows higher resolution imaging than “classical” single photon emission computed tomography (SPECT, using 99-technecium or other radioisotopes).
Nowadays, the available generators are using old technologies. Moreover, none of these generators is complying with the current good manufacturing practice (cGMP). The synthesis equipments currently on the market are complex, flexible but uneasy to use, because initially designed for research centers, and mostly not adapted to clinical use.
The goal of GAGE project is to make available a set of integrated equipment dedicated to the synthesis of molecules labeled with Gallium-68, adapted to clinical daily use and complying with the cGMP
Budget
This is a 4 years project with a total budget of 2,9 M€
Contact
Jean-Luc Morelle (coordinator of the project)
Email : morelle@trasis.com
Trasis SA
Web site : www.trasis.com
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