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Assembly of an artificial ovary combining isolated human ovarian follicles, fibrin and a textile pocket
Key words : Ovary, Fibrin, Textiles, Tissue Engineering, Fertility
Consortium
- Companies: Baxter R&D Europe (coordinator), SMI
- Research centers: Centexbel, UCL (Laboratory of Gynecology), Ulg (Laboratory of Tumor and Development Biology)
Topic of the project
The objective of this project is the development of a 3D biodegradable matrix allowing the graft of autologous ovarian tissue or isolated follicles in patients with impaired fertility following a gonadotoxic treatment. This biofunctional fibrin-based matrix will limit the follicular loss due to post-transplant ischemic stress and will help to induce the formation of an extracellular ovarian-like matrix by promoting cell migration, cell proliferation and vascularization.
In addition, a biodegradable textile pocket will also be developed to contain the tissue scaffold and to efficiently suture the graft at the implantation site.
Budget
This is a 4 year project with a total budget of 2, 2 M€
Contact
Patricia Meijers (coordinator of the project)
Email : patricia_meijers@baxter.com
Baxter R&D Europe
Web site: www.baxter.be
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