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IDDI* is pleased to invite you to a Symposium organized with the support from UCLouvain and EORTC: "Are Randomized Trials Obsolete ?"

Randomized clinical trials have often been criticized for being conducted in conditions that do not reflect the real world. There is an acute need for more and larger pragmatic trials that reflect clinical practice, but because these trials are conducted with tight budget and limited control, they are often considered as yielding unreliable or even misleading evidence of treatment benefits and harms. In addition, the recent advent of precision medicine has revived controversies about the role of randomization as a core feature in clinical trial design, for testing treatments that clearly have better efficacy than the current standards of care.

Finally, the availability of large databases of real world evidence has also led to questioning the necessity to carry out expensive and lengthy randomized clinical trials, if sophisticated statistical techniques (e.g., based on causal inference) could inform the choice between therapeutic options.

This symposium will address the sources of bias that continue to threaten sound clinical research now and in the foreseeable future. Past achievements and the current landscape will be described along with realistic proposals to move the field forward.

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*About IDDI

IDDI is an expert clinical data services and high-level strategic consulting contract research organization (CRO), providing agile clinical trials services for pharmaceutical, biotech, and medical device/diagnostic companies. With a proven track record, IDDI will help to ensure the successful execution of your clinical development program.

Auditorium Royal Museum of Fine Arts of Belgium Rue du Musée, 9 1000 Bruxelles

IDDI - Dominique Grisard : [email protected]

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